Researchers uncover mutation patterns in childhood mastocytosis
The commonly known KIT D816V mutation appeared only in systemic disease, while other KIT mutations were seen in skin-limited cases.
The commonly known KIT D816V mutation appeared only in systemic disease, while other KIT mutations were seen in skin-limited cases.
In patients with SM and blood cancer, a stem cell transplant rapidly removed the disease-causing mutation, but tryptase levels took longer.
Patients with systemic mastocytosis can safely extend venom immunotherapy (VIT) maintenance intervals to 12 weeks after five years.
Tryptase genotyping helps determine whether a high tryptase level reflects disease or genetics in systemic mastocytosis (SM).
Patients with systemic mastocytosis (SM) face significantly increased risks of melanoma and other skin cancers.
HT-KIT cut KIT protein levels by more than 80% and halted tumor growth in systemic mastocytosis (SM) models.
A patient with systemic mastocytosis suffered a life-threatening immune reaction after receiving an mRNA-1273 COVID-19 booster.
Results from a recent study could support more accurate diagnosis and future therapies in indolent systemic mastocytosis.
A clinical trial is testing avapritinib and decitabine to improve outcomes for patients with SM and an associated blood cancer.
The HARBOR study will compare elenestinib with a placebo and best supportive care to determine its effectiveness in treating ISM.