Skin-related symptoms are very common in systemic mastocytosisMastocytosis Rare disease caused by the buildup of mast cells. Cutaneous mastocytosis primarily affects the skin and is more common in children, while systemic mastocytosis affects internal organs and is more common in adults. (SM), affecting 85% of people living with the disorder.
Inflammation, itchiness, hives and flushing affecting the face, neck, chest, arms and legs are all ways in which the skin reacts. A rash is also common and is activated by the abnormal accumulation of mast cells under the skin and is made up of clusters of reddish-brown dots that are intensely itchy.
It is important to avoid triggering symptoms, but taking care of your skin can also help in managing symptom flare-ups when they do occur.
Learn more about SM signs and symptoms
What is SM?
SM is a rare white blood cell disorder which is diagnosed in both men and women around the age of 50 years old. Mast cells are part of the body’s immune system, and are found in the skin, internal organs and bones.
In SM patients, they proliferate uncontrollably and accumulate in the body and release excessive amounts of histamines and other chemicals into the bloodstream. This causes the body to react in different ways – skin inflammation, headache, fatigue, nausea, diarrhea, joint pain, palpitations, low blood pressure and mood changes. AnaphylaxisAnaphylaxis A severe allergic reaction that can turn fatal without treatment. Patients with SM are at a higher risk of developing anaphylaxis. is also a risk in severe allergic reactions.
Avoiding triggers for skin flare-ups
First, take care of your skin preventatively by avoiding symptom triggers. These may include certain foods, alcohol, sudden changes in temperature, friction on the skin, physical exertion, emotional stress, certain medication, strong odors, pollen or mold. They can activate an allergic reaction, triggering a symptomatic episode.
A healthy diet, regular low-impact physical activity and stress management techniques such as meditation will also benefit your overall feeling well-being and help you avoid triggers, thus making it easier to manage your skin-related symptoms.
Managing skin flare-ups
When your skin does become inflamed and itchy, it can be uncomfortable and sensitive. It may start as a rash and then develop into hives. Cool compresses are helpful in alleviating the rash and soothing the itch. Loose, natural fiber clothing will be more comfortable and allow the skin to breathe.
Best practices to maintain skin health focus on protecting it through gentle cleansing, adequate hydration and protection from the sun. Facial cleansers, sunscreens and moisturizers that are hypoallergenic and fragrance-free are recommended, as they lock in your skin’s moisture.
Your doctor may also recommend medication such as antihistaminesAntihistamines Medications that block the effects of histamine, the chemical found in mast cells that is responsible for many of the symptoms of SM, as well as many allergic reactions. to manage skin reactions or a topical cream containing corticosteroids. Another option for temporary relief from skin lesions is phototherapy.
